Best Karthus Runes

For Karthus, the optimal rune setup is Domination with Dark Harvest Keystone, yielding a 52.27% win rate, chosen in 57.14% of games, complemented by Precision as the secondary tree runes.

Domination
Domination
Keystone-1Keystone-1Keystone-1Keystone-1
Keystone-1Keystone-1Keystone-1
Keystone-1Keystone-1Keystone-1
Keystone-1Keystone-1Keystone-1Keystone-1
Domination
Precision
Keystone-1Keystone-1Keystone-1
Keystone-1Keystone-1Keystone-1
Keystone-1Keystone-1Keystone-1
OffenseOffenseOffense
FlexFlexFlex
DefenseDefenseDefense

Spells

Smite Exhaust

Starting Items

First buy

Scorchclaw PupHealth PotionStealth Ward

Best Karthus Build

The Liandry's Anguish has a 47.59% win rate and is used in 59.04% of all Karthus games. It is followed by Shadowflame and Rabadon's Deathcap as core legendary items for this build.

  1. 1st
    Sorcerer's Shoes
    →
  2. 2nd
    Liandry's Anguish
    →
  3. 3rd
    Shadowflame
    →
  4. 4th
    Rabadon's Deathcap
    →
    ⇅ Zhonya's Hourglass Rylai's Crystal Scepter
  5. 5th
    Void Staff
    →
    ⇅ Morellonomicon Demonic Embrace
  6. 6th
    Archangel's Staff
    ⇅ Horizon Focus
Best Champions
The best champions to play. Analyzed from the highest win rate matches.
Go to Tier List
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Skill Max Order

Priority

  1. Q
    Lay Waste
    →
    1st
  2. E
    Defile
    →
    2nd
  3. W
    Wall of Pain
    3rd

Ability Order

Leveling path

Lay Waste
Q
1
3
5
7
9
Wall of Pain
W
4
14
15
17
18
Defile
E
2
8
10
12
13
Requiem
R
6
11
16
Death Defied
P