Best Karthus Runes
For Karthus, the optimal rune setup is Domination with Dark Harvest Keystone, yielding a 52.27% win rate, chosen in 57.14% of games, complemented by Precision as the secondary tree runes.

Domination















Precision


















Spells
Starting Items
First buy
Best Karthus Build
The Liandry's Anguish has a 47.59% win rate and is used in 59.04% of all Karthus games. It is followed by Shadowflame and Rabadon's Deathcap as core legendary items for this build.
Best Champions
The best champions to play. Analyzed from the highest win rate matches.
Go to Tier List
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Skill Max Order
Priority
- 1st
- 2nd
- 3rd
Ability Order
Leveling path

Q
1
3
5
7
9

W
4
14
15
17
18

E
2
8
10
12
13

R
6
11
16

P