Vayne Counter Pick
The Best Vayne Counter Picks in League of Legends for patch 12.10, Ranked Boost recommends these picks due to their win condition and abilities.
Vayne is Weak Against
Statistically, these counter picks have a Higher Win Rate in patch 12.10. The strongest counter would be Draven, a hard to play champion who currently has a Win Rate of (Bad) and Play Rate of (High).
Most Popular Matchups
League of Legends most often picked champions vs Vayne, this is often heavily influenced by champion popularity.
You can find this champions most similar picks in league of legends based on role and playstyle here.