Diablo 2 Resurrected Io Rune will +10 vitality when socketed in a Weapon and +10 vitality if its an Armor. You can craft Io Runes with a Horadric Cube using 3 Hel + 1 Chipped Diamond (Ladder Only) and also has a chance to drop in Act 1 (Nightmare) Difficulty. This rune is also used in Runewords such as Memory, White, and Dream.
Io Rune Guide
Level Requirement: 35
Weapon Effect: +10 vitality
Armor Effect: +10 vitality
Shield Effect: +10 vitality
Quickly navigate this Io Guide using the links below.
How To Get Io Rune in Diablo 2
You can find Io Runes using various methods. Below we explain every way you can obtain a Io rune in diablo 2 Resurrected. Learn more about Runes by visting our D2 Rune Guide.
Method | How To Get |
---|---|
Countess | Nightmare and above |
Hell Forge | Nightmare and Hell |
Drop Chance | Act 1 (Nightmare) and above |
Horadric Cube Recipe | 3 Hel + 1 Chipped Diamond (Ladder Only) |

Advertisement
List of Io Runewords in Diablo 2
Below we display every Runeword you can make with the Io Rune in Diablo 2 Resurrected.
Note: You need to place the Runes in the correct order from Left to Right.
Runewords | Description |
---|---|
A Tier
Memory
1 ![]() 2 ![]() 3 ![]() 4 ![]() Lum + Io + Sol + Eth
4 Socket Staves
Requires Lv. 37
|
+3 to Sorceress Skill Levels
33% Faster Cast Rate Increase Maximum Mana 20% +3 Energy Shield (Sorceress Only) +2 Static Field (Sorceress Only) +10 To Energy +10 To Vitality +9 To Minimum Damage -25% Target Defense Magic Damage Reduced By 7 +50% Enhanced Defense |
A Tier
White
1 ![]() 2 ![]() Dol + Io
2 Socket Wand
Requires Lv. 35
|
Hit Causes Monster To Flee 25%
+10 To Vitality +3 To Poison And Bone Skills (Necromancer Only) +3 To Bone Armor (Necromancer Only) +2 To Bone Spear (Necromancer Only) +4 To Skeleton Mastery (Necromancer Only) Magic Damage Reduced By 4 20% Faster Cast Rate +13 To Mana |
A Tier
Dream
1 ![]() 2 ![]() 3 ![]() Io + Jah + Pul
3 Socket Helms/ Shields
Requires Lv. 65
|
10% Chance To Cast Level 15 Confuse When Struck
Level 15 Holy Shock Aura When Equipped +20-30% Faster Hit Recovery +30% Enhanced Defense +150-220 Defense +10 To Vitality Increase Maximum Life 5% (Helms Only) +50 To Life (Shields Only) +0.625-61.875 To Mana (Based On Character Level) All Resistances +5-20 12-25% Better Chance of Getting Magic Items |
B Tier
Delirium
1 ![]() 2 ![]() 3 ![]() Lem + Ist + Io
3 Socket Helms
Requires Lv. 51
|
1% Chance To Cast Level 50 Delirium (morph) When Struck
6% Chance To Cast Level 14 Mind Blast When Struck 14% Chance To Cast Level 13 Terror When Struck 11% Chance To Cast Level 18 Confuse On Striking +2 To All Skills +261 Defense +10 To Vitality 50% Extra Gold From Monsters 25% Better Chance of Getting Magic Items Level 17 Attract (60 Charges) |
C Tier
Pride
1 ![]() 2 ![]() 3 ![]() 4 ![]() Cham + Sur + Io + Lo
4 Socket Polearms
Requires Lv. 67
|
25% Chance To Cast Level 17 Fire Wall When Struck
Level 16-20 Concentration Aura When Equipped 260-300% Bonus To Attack Rating +1-99% Damage To Demons (Based on Character Level) Adds 50-280 Lightning Damage 20% Deadly Strike Hit Blinds Target Freezes Target +3 +10 To Vitality Replenish Life +8 1.875-185.625% Extra Gold From Monsters (Based on Character Level) |
F Tier
Black
1 ![]() 2 ![]() 3 ![]() Thul + Io + Nef
3 Socket Clubs/Hammers/Maces
Requires Lv. 35
|
+120% Enhanced Damage
40% Chance Of Crushing Blow +200 To Attack Rating Adds 3-14 Cold Damage - Cold Duration 3 Seconds +10 To Vitality 15% Increased Attack Speed Knockback Magic Damage Reduced By 2 Level 4 Corpse Explosion (12 Charges) |

Advertisement
Click/Tap to view other Class Guides below.

Amazon

Assassin

Barbarian

Druid

Necromancer

Paladin

Sorceress
Click/Tap the other Runes Guides below.

Amn

Ber

Cham

Dol

El

Eld

Eth

Fal

Gul

Hel

Ist

Ith

Jah

Ko

Lem

Lo

Lum

Mal

Nef

Ohm

Ort

Pul

Ral

Shael

Sol

Sur

Tal

Thul

Tir

Um

Vex

Zod
Click/Tap the other Runewords Guides below.



Ancient's Pledge





Beast



Black



Bone




Bramble






Breath Of The Dying





Call To Arms




Chains Of Honor



Chaos



Crescent Moon



Delirium





Doom



Duress



Enigma



Enlightenment





Eternity




Exile




Famine



Fury



Gloom




Hand Of Justice




Heart Of The Oak




Holy Thunder





Honor



King's Grace




Kingslayer


Leaf



Lionheart


Lore



Malice



Melody




Memory



Myth


Nadir




Passion



Peace


Prudence



Radiance



Rain


Rhyme



Sanctuary






Silence


Smoke


Splendor


Stealth


Steel


Strength




Stone



Treachery



Venom



Wealth


White


Wind


Zephyr




Brand





Death





Destruction



Dragon



Dream



Edge




Faith




Fortitude





Grief




Harmony




Ice




Infinity




Insight






Last Wish



Lawbringer




Oath





Obedience




Phoenix




Pride




Rift




Voice Of Reason




Wrath



Principle




Spirit
Advertisement